解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
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公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Hemodialysis (HD) prescription is usually based on the periodical measurement of the Kt/V achieved in a midweek dialysis session. The purpose of the study was to assess the duration of each HD session to achieve a target dose of dialysis. This allowed to determine whether a given dialysis session may be considered rep...
journal_title:Nephron
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000046041
更新日期:2001-09-01 00:00:00
abstract::Hyaluronic acid (HA) is a ubiquitous component of extracellular matrix. After tissue injury, HA appears in greater abundance during the inflammatory response and the phase of clearance of cell and matrix debris, before collagen production and matrix degradation. The aim of this study was to examine whether normal rat ...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000046019
更新日期:2001-08-01 00:00:00
abstract::Patients with familial lecithin-cholesterol acyltransferase (LCAT) deficiency very often show progressive glomerulosclerosis with evolution to end-stage disease. High levels of an abnormal lipoprotein (lipoprotein X) cause glomerular capillary endothelial damage. The ultrastructural study of renal biopsy specimens sho...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000046001
更新日期:2001-07-01 00:00:00
abstract::A previous study from our laboratory has shown that erythropoietin (EPO), beside its traditional role in erythropoiesis, acts as an alleviator of oxidative stress and inflammation in chronic hemodialysis (HD) patients, conferred in part by activated polymorphonuclear leukocytes (PMNLs). To substantiate this phenomenon...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000045991
更新日期:2001-07-01 00:00:00
abstract:OBJECTIVE:Urolithiasis and free radicals have long been associated. In this study, we have isolated calcium oxalate monohydrate (COM) binding proteins from rat kidney before and after lipid peroxidation (LPO) and studied its properties on calcium oxalate crystal growth. MATERIALS AND METHODS:LPO was carried out using ...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000045978
更新日期:2001-06-01 00:00:00
abstract::Recent findings of increased isoprene emission in the exhaled breath of patients undergoing haemodialysis and experimental evidence of the potential toxic and cancerogenic effects of isoprene hydrocarbon led us to assess how long haemodialysis patients are exposed to how much isoprene after a single haemodialysis sess...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000045958
更新日期:2001-05-01 00:00:00
abstract:BACKGROUND/AIM:Acute renal failure (ARF) is one of the common problems associated with sepsis or multiple organ dysfunction syndrome (MODS). We have investigated the effects of inhibiting selectin-mediated cell adhesion on lipopolysaccharide-induced ARF in rabbits, using sialyl Lewis X oligosaccharide and PB1.3, an ant...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000045942
更新日期:2001-04-01 00:00:00
abstract::The methylenetetrahydrofolate reductase (MTHFR) gene polymorphism has been shown to be associated with cardiovascular disease in healthy subjects as well as in patients with end-stage renal disease (ESRD). In this study, we examined the allelic frequency and genotype distribution of the MTHFR gene in 151 Chinese ESRD ...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000045922
更新日期:2001-03-01 00:00:00
abstract::In this study, we examined the hypothesis whether exogenous administration of L-lysine in drinking water would reduce nonenzymatic glycation of glomerular basement membrane (GBM) collagen and thus albuminuria in streptozotocin-diabetic rats. The rationale is that the administered lysine would combine with the circulat...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000045904
更新日期:2001-02-01 00:00:00
abstract::Primary hyperoxaluria type 1 (PH1) is caused by deficiency of peroxisomal alanine-glyoxylate aminotransferase which is in humans exclusively expressed in liver cells. The disease is inherited as an autosomal recessive trait, and initial symptoms usually occur in early childhood. Up to the age of 25 years, 90% of the p...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000045888
更新日期:2001-01-01 00:00:00
abstract::Efficacy and safety of a low-molecular-weight heparin (LMWH) were studied in 33 stable maintenance hemodialysis patients who had a bleeding tendency on unfractionated heparin. The optimal dose of LMWH for each patient was titrated before the study; the mean total LMWH dosage was 1,152 +/- 574 IU. No major bleeding or ...
journal_title:Nephron
pub_type: 临床试验,杂志文章
doi:10.1159/000045840
更新日期:2000-12-01 00:00:00
abstract::Cardiovascular disease remains the major cause of mortality in hemodialysis patients. Abnormal oxidative stress and impaired antioxidant defense may contribute to accelerated atherogenesis associated with uremia. As oxidative modification of lipids appears to be a prerequisite for the development of atherosclerotic le...
journal_title:Nephron
pub_type: 临床试验,杂志文章
doi:10.1159/000045830
更新日期:2000-12-01 00:00:00
abstract::We determined the clinical and immunopathological effects of dilazep hydrochloride (dilazep) on IgA nephropathy of ddY mice. Group I (early-treatment group, n = 10) was orally treated with 300 mg/kg body weight of this drug from 12 weeks of age until 60 weeks of age, and group II (late-treatment group, n = 10) was als...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000045788
更新日期:2000-11-01 00:00:00
abstract:BACKGROUND:The development of abnormalities in red blood cell (RBC) deformability in patients undergoing hemodialysis remains a major problem, because it is related to peripheral microcirculation, oxygen supply, and various complications in such patients. gamma-Linolenic acid (GLA; 18:3n-6), one of the polyunsaturated ...
journal_title:Nephron
pub_type: 临床试验,杂志文章
doi:10.1159/000045729
更新日期:2000-10-01 00:00:00
abstract:AIMS AND METHODS:This study was carried out to clarify whether the urinary excretion of type IV collagen (u-IV collagen) detected by specific radioimmunoassay, can be used as an indicator for the progression of diabetic nephropathy. RESULTS:u-IV collagen was higher in diabetic subjects with microalbuminuria and overt ...
journal_title:Nephron
pub_type: 临床试验,杂志文章
doi:10.1159/000045709
更新日期:2000-09-01 00:00:00
abstract::While the bulk of renal hypertrophy induced by contralateral nephrectomy or a high-protein diet consists of tubular cell growth, there is some evidence suggesting that mesangial cells play a role in this phenomenon. Previous data suggest that this role of mesangial cells is associated with their proliferation. We, the...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000045668
更新日期:2000-07-01 00:00:00
abstract:BACKGROUND/AIM:The ultrasonic transit time is currently the best method for measuring the blood flow rate in the extracorporeal hemodialysis circuit. The purpose of this study was to analyze the differences between blood flow as indicated by the hemodialysis blood roller pump (prescribed blood flow) and by an ultrasoni...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000045647
更新日期:2000-06-01 00:00:00
abstract:BACKGROUND/AIM:Interleukin-6 (IL-6) promotes the growth of renal mesangial cells. IL-6 may play a major role in such mesangial proliferation, but there has been little research on IL-6 in relation to diabetic nephropathy because of the difficulty in measuring urinary and serum IL-6 levels. Using a newly developed, high...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000045634
更新日期:2000-05-01 00:00:00
abstract:AIM:To determine the prevalence of kidney disease in a cohort of individuals with silicosis. METHODS:Review of medical records and questionnaires from patients reported to a state surveillance system for silicosis. Reporting of individuals with silicosis is required by state law. All individuals with silicosis reporte...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000045624
更新日期:2000-05-01 00:00:00
abstract::Decreased serum levels of high-density lipoprotein cholesterol (HDL-C) are a well-known risk factor for coronary heart disease (CHD) in the general population and have been suggested as one of the best predictor of CHD after renal transplantation. However, very heterogeneous HDL-C levels have been reported in renal tr...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000045608
更新日期:2000-04-01 00:00:00
abstract::Increased free-radical production leading to oxidative stress may contribute to the development of cardiovascular complications in haemodialysis patients. The ferroxidase activity of caeruloplasmin forms an important component of antioxidant defences in body fluids. The aim of this study was to assess ferroxidase acti...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000045579
更新日期:2000-03-01 00:00:00
abstract::Cardiovascular disease is a major cause of morbidity and mortality in patients with end-stage renal disease (ESRD). Epidemiological and clinical studies have shown that this is most frequently related to damage of large conduit arteries. Macrovascular disease develops rapidly in uremic patients and is responsible for ...
journal_title:Nephron
pub_type: 杂志文章,评审
doi:10.1159/000045557
更新日期:2000-02-01 00:00:00
abstract::Epidermal nevus syndrome is an unusual neurocutaneous disorder in which epidermal nevi are associated with abnormalities of the skeleton and central nervous system, including the eyes and somtimes the cardiovascular system. We treated a patient in whom the latter included renal artery stenosis. An 18-year-old man with...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000045540
更新日期:2000-01-01 00:00:00
abstract::We describe a pair of 17-year-old identical twin brothers with asymptomatic proteinuria, one of whom showed focal segmental glomerulosclerosis (FSGS) while the other showed immunoglobulin M (IgM) nephropathy. For each twin, audiological examination was normal. There was no family history of renal failure, deafness, or...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000045394
更新日期:1999-06-01 00:00:00
abstract::Cerebral salt-wasting syndrome (CSWS) has been regarded as a misnomer of the syndrome of inappropriate secretion of antidiuretic hormone (SIADH). We take the position that CSWS does exist and might be more common than SIADH. Differentiation between groups has been difficult because of overlapping signs, symptoms, and ...
journal_title:Nephron
pub_type: 杂志文章,评审
doi:10.1159/000045384
更新日期:1999-06-01 00:00:00
abstract::In order to estimate a regenerative response in the early phase after renal ischemia-reperfusion in rat, we examined the time course of the activation of epidermal growth factor receptor (EGFR) as a response of signal transduction pathway after 45 min ischemia in kidney. The activation of EGFR was observed 5-30 min af...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000045281
更新日期:1999-02-01 00:00:00
abstract::Abnormalities in plasma composition of essential fatty acids (EFAs) may be associated with the etiology of pruritus and other skin problems in patients undergoing hemodialysis. To study whether an oral supplementation with omega-6 (n-6) EFAs would restore deranged plasma EFAs and ameliorate skin symptoms, 9 and 7 dial...
journal_title:Nephron
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000045271
更新日期:1999-02-01 00:00:00
abstract::The present study was designed to determine the changes of the cyclin/CDK (cyclin dependent kinase)/CKI (CDK inhibitors) system in kidneys during pre- and postnatal development. All protein levels of cyclins (cyclins D1, D3, E, A, B) and protein levels and activities of CDKs (CDK4, CDK2, cdc2) were high in kidneys dur...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000045302
更新日期:1999-01-01 00:00:00
abstract::We measured levels of platelet-derived microparticles (PMP), which have coagulative activity and are produced by platelet activation or physical stimulation, and CD62P/CD63-positive platelets in patients with diabetes mellitus to determine their clinical significance and effects on complications of diabetes including ...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000045292
更新日期:1999-01-01 00:00:00
abstract::The study aimed to evaluate the behavior of alpha-glutathione S-transferase (alpha-GST) in the serum of hemodialysis patients with hepatitis C virus (HCV) infection following treatment with high-dose IFN-alpha-2b. Ten patients with detected anti-HCV antibodies and HCV RNA by RT-PCR were selected and treated with high-...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000045363
更新日期:1999-01-01 00:00:00
abstract::The purpose of this study was to identify and characterize humic compounds in Anticolana Valley (Fiuggi) water. The capacity of this class of compounds to mobilize metals from solid phases could have an important role in calculi solubilization. Humic compounds were isolated, purified and characterised by FTIR, 1H-NMR ...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000046304
更新日期:1999-01-01 00:00:00
abstract::Increasing urinary net acid (titratable acid + NH4 - HCO-3) excretion is accompanied by an increased urinary Ca excretion because of reduced renal tubular reabsorption of filtered Ca. The relationships between urinary Ca excretion rates and urinary net acid excretion rates are reviewed for data: (1) among healthy adul...
journal_title:Nephron
pub_type: 杂志文章,评审
doi:10.1159/000046294
更新日期:1999-01-01 00:00:00
abstract::To determine whether there are early renal function parameters (RFP) which can be monitored to rapidly detect nephrotoxicity induced by contrast media (CM), we observed RFP in 16 patients with normal renal function before and after administration of CM. Forty-eight hours after diatrizoate meglumine administration, blo...
journal_title:Nephron
pub_type: 临床试验,杂志文章
doi:10.1159/000045488
更新日期:1999-01-01 00:00:00
abstract::Obstructed shunt vessels were studied immunohistochemically to clarify the mechanism of shunt obstruction in hemodialysis patients. The subjects were 12 hemodialysis patients with shunt obstruction, and 8 patients newly started on hemodialysis were used as the controls. Cryosections of shunt tissue were prepared and s...
journal_title:Nephron
pub_type: 临床试验,杂志文章
doi:10.1159/000045256
更新日期:1999-01-01 00:00:00
abstract:BACKGROUND:Haemophilus influenzae infection is a mild and self-limited disease in the healthy population. However, it may show an aggressive course in the immunocompromised state which underlines the importance of vaccination against this agent. On the other hand, posttranplant immunosuppression may impair immune respo...
journal_title:Nephron
pub_type: 临床试验,杂志文章
doi:10.1159/000045246
更新日期:1999-01-01 00:00:00
abstract::In kidney allografts, focal segmental glomerulosclerosis (FSGS) has been described as recurrent, de novo, or a histological variant of chronic transplant glomerulopathy. We describe a unique case of de novo FSGS in a renal transplant not accompanied by any feature of rejection in a patient who had not been immunosuppr...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000045412
更新日期:1999-01-01 00:00:00
abstract::We report a case of rapidly progressive glomerulonephritis due to antiglomerular basement membrane (anti-GBM) antibodies that progressed to end-stage renal disease in a 35-year-old man who used intranasal cocaine on an occasional basis. In contrast to many prior reports of acute renal failure occurring with cocaine-as...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000045328
更新日期:1999-01-01 00:00:00
abstract::Dysfunction of the host defense against infection in hemodialysis (HD) patients has major clinical and socioeconomic implications. T helper type 1 (Th1) and type 2 (Th2) cytokines are implicated in regulating the immune responses and, therefore, may be involved in impaired status. The present study was designed to exa...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000045516
更新日期:1999-01-01 00:00:00
abstract:AIM:To clarify the role of leukocyte subsets in the development of glomerulosclerosis (GS) and interstitial lesions which may contribute to the prognosis of membranous nephropathy (MN), we investigated infiltrating cells in both glomeruli and interstitium in biopsy specimens. METHODS:Forty-one cases of MN were divided...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000045213
更新日期:1998-12-01 00:00:00
abstract::CBA/CaH-kdkd mice develop hereditary tubulointerstitial disease with mononuclear cell infiltration and cyst formation, possibly representing a model of human nephronophthisis. The purpose of the present investigation was to examine the components of the fibrotic changes which typically develop in the kidneys of these ...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000045191
更新日期:1998-11-01 00:00:00